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Stephen Yao Gbedema

Pharmaceutics

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About

Stephen Yao Gbedema is a Professor of Pharmaceutical Microbiology and the immediate past Head of Department of Pharmaceutics (October 2019 to November 2023), Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, KNUST, Kumasi, Ghana.  He was the formal Head of the KNUST Herbal Medicine Department (November 2016 to July 2018).  Prof. Gbedema completed his PhD degree in 2014 on a Commonwealth Split-Site Scholarship programme at the School of Pharmacy, University of Bradford, Bradford (UK Site) and KNUST (Home site).  He was appointed to lecture in the Department of Pharmaceutics, KNUST in July 2003 after completion of M.Pharm (2002) degree from the same Department.  He also hold a B.Pharm (1998) degree, is a registered pharmacist with over 24 years of experience in pharmaceutical care provision, and a member of the Pharmaceutical Society of Ghana.  He is also a member of the West African Health Organization (WAHO) Expert Committee on Traditional Medicine and World Health Organization (WHO) International Expert Committee on Traditional, Complementary and Integrative Medicine. He is a visiting professor to the Madonna University School of Pharmacy at Elele – Port Harcourt in Nigeria.For his secondary education, Prof. Gbedema attended the then Abor Experimental Junior Secondary School and passed the West African Examination Council Junior Secondary School Leaving Certificate Examination in June 1985. He proceeded to St. Paul’s Secondary School at Denu – Hatsukope in the Volta Region (for GCE ‘O’ Level; 1989) and Labone Secondary School in Accra (for GCE ‘A’ Level; 1991).  Prof. Gbedema is passionate about traditional medicine practices involving the use of herbs and other natural products in the treatment of infections including malaria and the Neglected Tropical Diseases.  His PhD research and most other research studies he conducted were on developing phyto-medicines from folklore herbs for managing infectious conditions. For instance, after demonstrating that extracts of plants, like Polyalthia longifolia, possess anti-plasmodial activity against multidrug resistant strains of Plasmodium falciparum, he together with his research team formulated the extracts into appropriate dosage forms with improved efficacy for treating malaria in both adults and children.Another folklore herb of much interest to Prof. Gbedema is Cryptolepis sanguinolenta popularly called the Ghana-Quinine because of its common use in malaria (and sometimes cancer) management in Ghana. Prof. Gbedema and his research team isolated the active constituent of this plant, cryptolepine, and synthesized various analogues of it which were screened against multidrug resistant strains of pathogens and a number of cancer cell lines, for their potential application in the treatment of infectious diseases and cancer.Other studies he undertook included; Assessing the stability of hospital compounded extemporaneous oral formulations; Screening of microbial metabolites for bioactive compounds for antibiotic drug development; Developing oral thin films as a remedy for drug compliance in paediatric and geriatric patients; Evaluating the challenges and knowledge gaps in malaria therapy as a stakeholder approach to improving oral quinine use in the treatment of childhood malaria; Investigating HIV-1 patients failing protease inhibitor antiretroviral therapy for HIV resistant mutants; and the Efficacy of disinfectants commonly used in some health facilities in the Kumasi metropolis of Ghana. He has published his research findings in pear reviewed international journals and also attended numerous scientific conferences.  Prof. Gbedema is a teacher and a mentor in the pharmaceutical microbiology discipline; he lectures in various topics to undergraduate and postgraduate students in pharmacy and some other health-related programmes in the College of Health Sciences.  Many of his past graduate students hold various positions in research and academic institutions in Ghana and abroad.

Research Summary

(inferred from publications by AI)

The researcher's work is a comprehensive synthesis of studies across multiple domains, particularly emphasizing their focus on understanding and controlling malaria infections, the role of traditional and medicinal extracts, the development of complementary and alternative treatments, and the broader impact of microbial natural products. Their research delves into antibiotic resistance patterns in various organisms, the effects of essential oils on antimicrobial activity, the synthesis of trypanotic compounds for therapeutic use, and the contribution of alkaloids to malaria control. The researcher's work spans health sciences, life sciences, pharmacology, and biochemistry, highlighting their holistic approach to understanding microbial natural products and their applications in public health.

Research Themes

All Papers

The prevalence of malaria among HIV seropositive individuals and the impact of the co- infection on their hemoglobin levels(2015)
The Challenges and Knowledge Gaps in Malaria Therapy: A Stakeholder Approach to Improving Oral Quinine Use in the Treatment of Childhood Malaria in Ghana(2018)
Antimicrobial Activity Of Essential Oils Of <i>Xylopia aethiopica</i>(2008)
Clerodane diterpenes from Polyalthia longifolia (Sonn) Thw. var. pendula: Potential antimalarial agents for drug resistant Plasmodium falciparum infection(2015)
In Vivo Antimalarial Activity of Polyalthia longifolia (Annonaceae) Leaf Extract and Assessment of Its Formulated Oral Dosage Forms(2021)
Concurrent Use of Herbal and Orthodox Medicines among Residents of Tamale, Northern Ghana, Who Patronize Hospitals and Herbal Clinics(2018)
Occurrence, species distribution and antibiotic resistance of Proteus isolates: A case study at the Komfo Anokye Teaching Hospital (KATH) in Ghana(2010)
Antibiotic producing microorganisms from River Wiwi, Lake Bosomtwe and the Gulf of Guinea at Doakor Sea Beach, Ghana(2012)
Antimicrobial Potential of Extract from a Pseudomonas aeruginosa Isolate(2022)
Prevalence and antibiotic resistance of coagulase-negative <em>Staphylococci</em> isolated from poultry farms in three regions of Ghana(2017)
Oral Thin Films As a Remedy for Noncompliance in Pediatric and Geriatric Patients(2019)
Wound healing properties and kill kinetics of<i>Clerodendron splendens</i>G. Don, a ghanaian wound healing plant(2010)
The antimicrobial activity of Croton membranaceus, a species used in formulations for measles in Ghana(2009)
Phytochemical Investigation and Anti-Microbial Activity of &lt;i&gt;Clausena Anisata&lt;/i&gt; (Willd), Hook.(2014)
Appraisal of the Constituent Plant Materials in a Ghanaian Antifungal Herbal Product; An in vitro Interactive Combination Analysis and a Pilot Clinical Study to Determine Efficacy.(2019)
Antibiotic Resistance Patterns of <i>Escherichia coli</i> Isolates from Hospitals in Kumasi, Ghana(2012)
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity(2015)
Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer(2022)
Clinical characteristics of external bacterial ocular and periocular infections and their antimicrobial treatment patterns among a Ghanaian ophthalmic population(2022)
Clinical Characteristics of External Ocular and Periocular Infections and Their Antimicrobial Treatment Patterns Among a Ghanaian Ophthalmic Population; A Multicenter Study(2022)
Enteric Protozoan Parasitosis and Associated Factors among Patients with and without Diabetes Mellitus in a Teaching Hospital in Ghana(2023)
Resistance to protease inhibitors among persons living with HIV in Ghana: a case for viral load and drug resistance monitoring(2024)
Resistance to protease inhibitors in human immunodeficiency virus infection in Ghana: a case for viral load and drug resistance monitoring(2023)
Adherence to Hygiene Protocols and Doxycycline Therapy in Ameliorating Lymphatic Filariasis Morbidity in an Endemic Area Post-Interruption of Disease Transmission in Ghana(2024)
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines(2014)
Preliminary health risk assessment of two exudate gums as pharmaceutical excipients(2023)
Wound Healing and Acute Dermal Toxicity Studies of <i>Ludwigia octovalvis</i> (Jacq.) P. H. Raven (Onagraceae) in <i>Sprague–Dawley</i> Rats(2024)
Physicochemical Characterisation and Potential Uses of Oils From the Entrails of Nile Tilapia From Different Farming Sites in Ghana(2025)
ACCURACY OF DIAGNOSIS OF INTESTINAL HELMINTH PARASITES IN A REFERENCE DIAGNOSTIC LABORATORY IN THE ASHANTI REGION OF GHANA(2011)
PREVALENCE OF SCHISTOSOMA HAEMATOBIUM INFECTION IN GHANA: A RETROSPECTIVE CASE STUDY IN KUMASI(2011)
The Immunostimulatory and Antimicrobial Property of two Herbal Decoctions used in the Management of Hiv/Aids in Ghana(2014)
Enhancement of antibacterial activity of amoxicillin by some Ghanaian medicinal plant extracts(2010)
Animals traded for traditional medicine in Ghana: their zootherapeutic uses and implications for biodiversity conservation(2025)
Antitrypanosomal and Anthelminthic Properties of Ethanol Extracts of Carica papaya Linn. and Ceiba pentandra (L) Gaertn.(2022)
Antibiotic susceptibility patterns of Salmonella typhi among patients in three hospitals in Kumasi, Ghana.(2014)
Antimicrobial Property of Microorganisms Isolated from Soil and Water – Body Samples in Ghana(2022)
Isolation of antibiotic Producing Microorganisms from some water bodies within Eastern and Greater Accra Regions of Ghana(2019)
Assessment of the physico-chemical and microbial quality of selected extemporaneous paediatric oral formulations frequently prepared at Komfo Anokye Teaching Hospital in Kumasi(2020)
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The Consumption of Energy Drink and Its Potential Effect on Sleep Patterns: A Case Study in the Kumasi Metropolis(2023)
CCDC 2155900: Experimental Crystal Structure Determination(2022)
CCDC 2155899: Experimental Crystal Structure Determination(2022)
Phytochemical Profile, In Vitro Antimicrobial and Anthelmintic Properties of Dichrostachys Cinerea Root Extracts(2025)

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.