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Seth Agyei Domfeh

Biochemistry and Biotechnology

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About

Seth is a Lecturer in the Department of Biochemistry and Biotechnology at Kwame Nkrumah University of Science and Technology (KNUST), Kumasi. He is a certified Medical Laboratory Scientist, as recognised by the Allied Health Professions Council in Ghana, with over a decade of experience in clinical laboratory practice before joining KNUST.Seth holds a BSc in Medical Laboratory Technology, an MPhil in Immunology, and an MEd in Educational Planning and Administration from KNUST, as well as a PGDip in Teaching and Learning in Higher Education from the University of Education, Winneba. Seth was a PhD Fellow at the West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) in Ghana, under the esteemed Wellcome Trust - Developing Excellence in Leadership, Training, and Science in Africa (DELTAS) programme. He afterwards graduated with a PhD in Molecular Cell Biology of Infectious Diseases from the University of Ghana, Legon.His research focuses on elucidating how toxins interact with the hepatitis B virus to promote liver cancer, discovering anticancer agents from medicinal plants, and identifying drugs that block the transmission of the malaria parasite. To advance his expertise in malaria research, he received the prestigious Africa Research Excellence Fund (AREF) Research Development Fellowship, which enabled him to receive training at the London School of Hygiene and Tropical Medicine. He was also a Visiting Researcher at the Africa Microscopy Initiative Imaging Centre in South Africa, where he gained advanced bioimaging skills.His professional services include reviewing for reputable journals such as Cancer Reports, Health Science Reports, and the Journal of Ethnopharmacology, as well as serving as an Academic Editor for PLOS One. Through his work, Seth aims to advance the discovery of innovative therapies and empower the next generation of African scientists.

Research Summary

(inferred from publications by AI)

The researcher has conducted extensive research focusing on infectious diseases, with a particular emphasis on mosquito-borne infections (such as chikungunya virus and hepatitis B virus) and the natural science domain, utilizing plant-based agents like Cryptolepine.

Research Themes

All Papers

Evidence of chikungunya virus infections among febrile patients at three secondary health facilities in the Ashanti and the Bono Regions of Ghana(2021)
Immunosurveillance and molecular detection of hepatitis B virus infection amongst vaccinated children in the West Gonja District in Savanna Region of Ghana(2021)
Cryptolepine and Nibima inhibit hepatitis B virus replication(2021)
Evaluation of inflammatory and liver injury biomarkers among drug-naive viral hepatitis B patients: A study in a referral laboratory, Ghana(2022)
Cryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling(2021)
Cryptolepine consolidates its anticancer potential by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes(2021)
Cryptolepine consolidates its anticancer potential by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes(2021)
Cryptolepine consolidates its anticancer property by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes(2020)
Cryptolepine, a plant-derived alkaloid, differentially regulates signal transduction pathways in human embryonic kidney (HEK293) cells(2023)
A CRYPTOLEPIS SANGUINOLENTA-BASED PREPARATION REDUCED HOSPITAL STAY AND MORTALITY OF COVID-19 PATIENTS DURING THE PANDEMI(2025)
Asymptomatic Bacteriuria and Anti-Microbial Susceptibility Patterns among Women of Reproductive Age. A Cross-Sectional Study in Primary Care, Ghana(2018)
Bacteriuria Among Type 2 Diabetes Mellitus Patients Attending Ejisu Government Hospital in the Ashanti Region, Ghana(2024)
Evaluation of Anti‐<i>Candida albicans</i> Activities of Herbal Preparations Sold at the Kumasi Central Market in the Ashanti Region of Ghana(2023)
Evaluation of Four Malaria Rapid Diagnostic Test Kits Used at the Enyiresi Government Hospital in the Eastern Region of Ghana(2023)
In vitro antiproliferative activities of some Ghanaian medicinal plants(2024)
A bioactive fraction from the leaves of Ceiba pentandra (L.) Gaertn. exhibits antiproliferative activity via cell cycle arrest at the G1/S checkpoint and initiation of apoptosis via poly [ADP-ribose] polymerase 1 (PARP1) cleavage in HeLa cells.(2025)
Comparative study of Widal test to stool culture for the diagnosis of suspected typhoid fever: a study in a primary health centre, Ghana(2023)
Postprandial glycemic responses of four common Ghanaian meals(2019)
The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways(2022)
In Vitro Cytotoxic Activity of Five Ghanaian Plants on Human Cancer Cell Lines(2024)
In vitro cytotoxic activity of five Ghanaian plants on human cancer cell lines(2024)

Collaboration Network

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.