Reimmel Kwame Adosraku

Pharmaceutical Chemistry

About

Reimmel K Adosraku completed his BPharm programme at KNUST with a 2nd Class Upper degree in 1980. After a 1-year national service in the Department of Pharmaceutical Chemistry, KNUST, he enrolled in the MPhil programme in Pharmaceutical Chemistry in 1981, which programme he successfully completed in 1984 and was employed as lecturer in the same department in 1984. In October 1990, he was admitted into the University of London School of Pharmacy, the premier School of Pharmacy in the UK, for a PhD programme in Bioanalytical Chemistry. He successfully completed the programme and returned to post in June 1994. Reimmel became instrumental in the promotion and application of high performance liquid chromatography (hplc) in the university. This greatly enhanced research in the department and turned out many Pharmaceutical Analysts for the pharmaceutical industries in Ghana who could apply this versatile technique in the analysis of medicines and other chemicals. He also introduced the practice of 'bench fees' in the department which provided essential funds for provision of research inputs so that graduate students were able to complete their programmes on schedule. This practice was later adopted by the university.

Research Summary

(inferred from publications by AI)

The researcher has conducted extensive work on bioactive compounds derived from natural products across diverse families, employing methodologies such as NMR lipid profiles and high-resolution mass spectrometry for characterization. These compounds, including plumbagin from *Plumbago zeylanica* and Xylopia aethiopica from *Xylopia aethiopica*, hold significant potential in health sciences for therapeutic applications. The researcher also explores antimicrobial residues, highlighting the importance of proper handling to prevent adverse effects in public health settings. Through these integrative approaches, the focus is on understanding and developing natural products with specific health benefits across pharmacology, biochemistry, and environmental impact assessments.

Research Themes

All (34 Papers)

Life Sciences (21 Papers)

Health Sciences (10 Papers)

Physical Sciences (3 Papers)

All Papers

Resistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from Plumbago zeylanica Linn(2019)

Investigation of Acid-Base Indicator Property of Plumbagin fromPlumbago zeylanicaLinn(2019)

NMR lipid profiles of cells, tissues, and body fluids: proton NMR analysis of human erythrocyte lipids.(1994)

Tetrahymena thermophila: analysis of phospholipids and phosphonolipids by high-field 1H-NMR(1996)

Proton Nuclear Magnetic Resonance Lipid Profiling of Intact Platelet Membranes(1995)

Antibacterial secondary metabolites from an endophytic fungus, Fusarium solani JK10(2017)

Ethnopharmacological Importance of Xylopia aethiopica (DUNAL) A. RICH (Annonaceae) - A Review(2016)

Effects of an ethanol extract and the diterpene, xylopic acid, of Xylopia aethiopica fruits in murine models of musculoskeletal pain(2016)

MALDI–HRMS imaging and HPLC–HRESI–MSn characterisation of kaurane diterpenes in the fruits of <scp>Xylopia aethiopica</scp> (Dunal) A. Rich (Annonaceae)(2019)

Exposure of consumers to substandard antibiotics from selected authorised and unauthorised medicine sales outlets in Ghana(2020)

Correction to: Detection and quantification of antibiotic residues in urine samples of healthy individuals from rural and urban communities in Ghana using a validated SPE-LC-MS/MS method(2020)

Substandard antibacterial agents in the formal and informal medicine outlets in Ghana: Still myth or reality?(2018)

Veterinary Medicine and Pharmaceuticals(2019)

Prenylated 2-arylbenzofuran derivatives with potent antioxidant properties from Chlorophora regia (Moraceae)(2015)

An HPLC method for the direct assay of the serotonin precursor, 5‐hydroxytrophan, in seeds of Griffonia simplicifolia(2002)

SYNTHESIS AND EVALUATION OF ANTIMICROBIAL PROPERTIES OF AZO DYES(2015)

Evaluation of the Haematinic Activities of Extracts of Justicia secunda Vahl Leaves in Red Blood Cells of Laboratory Rats(2020)

Evaluation of the Haematinic Activities of Extracts of &lt;i&gt;Justicia secunda&lt;/i&gt; Vahl Leaves in Red Blood Cells of Laboratory Rats(2020)

A Simple RP-HPLC Method to Simultaneously Assay the Contents of Lamivudine, Tenofovir, and Nevirapine in Fixed Dose Combined Oral Antiviral Medicines(2020)

Evaluation of the antioxidant and free radical scavenging properties of Secamone afzelii Rhoem.(2004)

CHARACTERIZATION AND HPLC QUANTIFICATION OF PIPERINE ISOLATED FROM PIPER GUINEENSE (Fam. PIPERACEAE)(2013)

Synthesis and Characterization of Novel Xylopic Acid Derivatives(2016)

Proton NMR lipid profile of Leishmania donovani promastigotes(1993)

Detection and quantification of antibiotic residues in urine samples of healthy individuals from rural and urban communities in Ghana using a validated SPE-LC-MS/MS method(2020)

Antimicrobial Activities of Novel Xylopic Acid Derivatives(2019)

A comparative study of Ghanaian propolis extracts: Chemometric analysis of the chromatographic profile, antioxidant, and hypoglycemic potential and identification of active constituents(2023)

A Comparative Study of Ghanaian Propolis Extracts: Chemometric Analysis of the Chromatographic Profile, Antioxidant, and Hypoglycaemic Potential and Identification of Active Constituents(2023)

LC–HRESI–MS/MS Profiling of Flavonoids from Chlorophora regia (Moraceae)(2017)

Investigating the In-vivo Antiplasmodial Properties of Aqueous Extract of Moringa oleifera Lam (Moringaceae) Leaves(2015)

Bioequivalence studies of cetirizine tablets using the urine excretion data of healthy Ghanaian male volunteers(2023)

Bioequivalence Study of Locally Manufactured Cetirizine Tablets in Ghana(2021)

Nuclear magnetic resonance and chromatographic studies of host and parasite lipids(1994)

Assessment of bioequivalence profile of locally produced flucloxacillin sodium capsules via urinary excretory rates(2016)

CCDC 1487779: Experimental Crystal Structure Determination(2017)

Collaboration Network

218d7031-8da6-483f-96af-2376be4b4342

Research Collaboration Map

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.