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Philip Kwadzo Selorm Segbefia

Molecular Medicine

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About

Selorm is an immunologist with a strong foundation in biomedical research and extensive experience in both academic and clinical laboratory settings. He earned his PhD in Immunology (2024) from Kwame Nkrumah University of Science and Technology (KNUST), Ghana. His doctoral research focused on assessing immune responses to Plasmodium falciparum in individuals with and without chronic hepatitis B virus (HBV) infection in Accra, Ghana. Utilizing advanced immunological techniques, including cytokine profiling via a 13-plex Luminex assay, his study provided critical insights into the potential impacts of chronic HBV on malaria vaccine efficacy in HBV-endemic regions. This work led to the publication of a review and two peer-reviewed research articles. Selorm also holds an MSc in Molecular Medicine from the University of Reading, UK (2019), where he honed his expertise in molecular biology techniques such as CRISPR/Cas9 gene editing, RNA extraction, and plasmid construction. His research project explored the role of *Phospholipase C gamma 2* (PLC-γ2) mutations in ibrutinib resistance in chronic lymphocytic leukemia, highlighting potential therapeutic targets within the B-cell receptor signaling pathway. His academic journey began with a BSc in Medical Laboratory Technology (First Class Honours) from the Garden City University College, an institution affiliated to the KNUST (2017) and a Diploma in Medical Laboratory Technology (Distinction) from the College of Health and Well Being, Ghana (2010). Over the years, he has developed skills in haematology, clinical chemistry, medical microbiology, and molecular biology, culminating in a research dissertation on the association between haemoglobin variants, blood group systems, and malaria parasitaemia in children. Professionally, Selorm has contributed significantly to research and teaching. As a Graduate Research Officer with the HEPMAL Project at the Noguchi Memorial Institute for Medical Research, Ghana, he conducted studies on immune system modulation and the effects of chronic HBV on malaria vaccine efficacy. Additionally, as a Senior Technician at KNUST, he has guided undergraduate students through practical biochemistry lessons and supported their research projects. Earlier in his career, he spearheaded the establishment of the Laboratory at the Essam Government Hospital, where he was part of the team who commenced the operations of this new hospital.  Selorm's research interests include the development of point-of-care devices to improve chronic hepatitis care, malaria vaccine development, and the impact of chronic hepatitis B infections on immune competence.

Research Summary

(inferred from publications by AI)

This researcher has focused on advancing our understanding of complex biological processes by integrating computational modeling with experimental biology. Their work emphasizes the use of mathematical optimization techniques to improve cancer treatment delivery and the development of biodegradable surfaces for environmental applications. By combining rigorous computational methods with in vivo experiments, they contribute to both fundamental biological research and practical technological innovations.

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.