Peter Arthur

English

About

I am a Senior Lecturer, formerly the Head of the Department of English and now the Head of Department of Language and Communication Sciences, KNUST. My area of specialization is text analysis in literature, traditional and contemporary cultures. I love how language intersects with culture and this has led me to research a lot more in oral literature. I am currently working on the Ghanaian folktale, Anansesem, and the potential it holds for Ghanaian pedagogy, morality and philosophy. I also love working on the literariness and performances of Ghanaian traditional festivals. On the other side is my research in Ghanaian contemporary culture spanning over the period of highlife to that of hiplife.

Research Summary

(inferred from publications by AI)

The researcher's work is centered on the comprehensive study of multiple sclerosis (MS), focusing on its molecular mechanisms, advanced treatment therapies, and innovative imaging techniques. They have significantly contributed to the field by developing interferon-based therapies like fingolimod and natalizumab, as well as B-cell immunotherapy, which are pivotal in advancing MS management. Additionally, they have made strides in advancing retinal OCT technology through specific studies on optic neuritis, demonstrating their expertise in both treatment development and medical imaging. Their research also delves into the immune response, exploring how B-cells trigger T cells to cause disease progression, highlighting a deep integration of biological, clinical, and technological advancements in understanding and treating multiple sclerosis.

Research Themes

All Papers

Defining the clinical course of multiple sclerosis(2014)

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis(2010)

Multiple Sclerosis(2018)

Natalizumab plus Interferon Beta-1a for Relapsing Multiple Sclerosis(2006)

Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double‐blind placebo‐controlled multicenter trial(2009)

Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial(2014)

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial(2011)

Rituximab in relapsing‐remitting multiple sclerosis: A 72‐week, open‐label, phase I trial(2008)

Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis(2007)

Pegylated interferon beta-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study(2014)

Imaging outcomes for neuroprotection and repair in multiple sclerosis trials(2009)

Optical coherence tomography reflects brain atrophy in multiple sclerosis: A four‐year study(2015)

Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis(2010)

Longitudinal multiple sclerosis lesion segmentation: Resource and challenge(2017)

The incidence and significance of anti-natalizumab antibodies(2007)

Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography(2011)

Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study(2016)

Optical coherence tomography and disease subtype in multiple sclerosis(2007)

Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies(2009)

Gadolinium-based MRI characterization of leptomeningeal inflammation in multiple sclerosis(2015)

Microcystic macular oedema, thickness of the inner nuclear layer of the retina, and disease characteristics in multiple sclerosis: a retrospective study(2012)

Diagnosis and classification of optic neuritis(2022)

The efficacy of natalizumab in patients with relapsing multiple sclerosis: subgroup analyses of AFFIRM and SENTINEL(2009)

Relationships Between Retinal Axonal and Neuronal Measures and Global Central Nervous System Pathology in Multiple Sclerosis(2013)

Diagnosis and management of multiple sclerosis.(2004)

Macular Volume Determined by Optical Coherence Tomography as a Measure of Neuronal Loss in Multiple Sclerosis(2009)

Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis(2013)

Association of Cortical Lesion Burden on 7-T Magnetic Resonance Imaging With Cognition and Disability in Multiple Sclerosis(2015)

Locus for severity implicates CNS resilience in progression of multiple sclerosis(2023)

The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain(2005)

MRI of the corpus callosum in multiple sclerosis: association with disability(2010)

Safety and efficacy of opicinumab in patients with relapsing multiple sclerosis (SYNERGY): a randomised, placebo-controlled, phase 2 trial(2019)

Neuropsychiatric syndromes of multiple sclerosis(2017)

Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study(2020)

Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics(2014)

Sensorimotor dysfunction in multiple sclerosis and column-specific magnetization transfer-imaging abnormalities in the spinal cord(2009)

Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis(2015)

Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study(2019)

In vivo identification of morphologic retinal abnormalities in neuromyelitis optica(2013)

Differentiating neuromyelitis optica from other causes of longitudinally extensive transverse myelitis on spinal magnetic resonance imaging(2015)

Volumetric Analysis from a Harmonized Multisite Brain MRI Study of a Single Subject with Multiple Sclerosis(2017)

Impact of Fingolimod Therapy on Magnetic Resonance Imaging Outcomes in Patients With Multiple Sclerosis(2012)

Imaging chronic active lesions in multiple sclerosis: a consensus statement(2024)

Peginterferon beta-1a in multiple sclerosis: 2-year results from ADVANCE(2014)

Revisiting Brain Atrophy and Its Relationship to Disability in Multiple Sclerosis(2012)

Guidance for use of neurofilament light chain as a cerebrospinal fluid and blood biomarker in multiple sclerosis management(2024)

Metabolic alterations in multiple sclerosis and the impact of vitamin D supplementation(2017)

Tract probability maps in stereotaxic spaces: Analyses of white matter anatomy and tract-specific quantification(2007)

High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cord(2007)

Diffusion Tensor Magnetic Resonance Imaging of Wallerian Degeneration in Rat Spinal Cord after Dorsal Root Axotomy(2009)

Damage to the Optic Radiation in Multiple Sclerosis Is Associated With Retinal Injury and Visual Disability(2009)

Probing mouse brain microstructure using oscillating gradient diffusion MRI(2011)

Saccade preparation inhibits reorienting to recently attended locations.(1989)

A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis(2021)

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination(2019)

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)(2019)

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity(2018)

Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis(2010)

Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis(2011)

Optical coherence tomography: a window into the mechanisms of multiple sclerosis(2008)

Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria(2014)

Visual dysfunction in multiple sclerosis correlates better with optical coherence tomography derived estimates of macular ganglion cell layer thickness than peripapillary retinal nerve fiber layer thickness(2011)

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration(2011)

Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis(2017)

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases(2006)

Abnormal B‐cell cytokine responses a trigger of T‐cell–mediated disease in MS?(2009)

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial(2000)

Anti-CD20 therapy depletes activated myelin-specific CD8<sup>+</sup>T cells in multiple sclerosis(2019)

Association of human herpes virus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA(1997)

Chemotherapy of Neoplastic Diseases(1962)

The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS(2003)

Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases(2005)

The APOSTEL recommendations for reporting quantitative optical coherence tomography studies(2016)

Statistical normalization techniques for magnetic resonance imaging(2014)

A topology-preserving approach to the segmentation of brain images with multiple sclerosis lesions(2009)

Saccade preparation inhibits reorienting to recently attended locations.(1989)

High-dose intravenous methotrexate for patients with nonleukemic leptomeningeal cancer: is intrathecal chemotherapy necessary?(1998)

Retinal layer segmentation of macular OCT images using boundary classification(2013)

APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies(2021)

Structured layer surface segmentation for retina OCT using fully convolutional regression networks(2020)

Anti-α4 integrin therapy for multiple sclerosis(2005)

Ganglion Cell Loss in Relation to Visual Disability in Multiple Sclerosis(2012)

Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein(2013)

Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning(2012)

Alterations in the retinal vasculature occur in multiple sclerosis and exhibit novel correlations with disability and visual function measures(2019)

DeepHarmony: A deep learning approach to contrast harmonization across scanner changes(2019)

Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior(2018)

Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation(2020)

Immune reconstitution inflammatory syndrome in the CNS of HIV-infected patients(2006)

Evaluating White Matter Lesion Segmentations with Refined Sørensen-Dice Analysis(2020)

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis(2008)

Cell-based therapeutic strategies for multiple sclerosis(2017)

SMORE: A Self-Supervised Anti-Aliasing and Super-Resolution Algorithm for MRI Using Deep Learning(2020)

Applications of a deep learning method for anti-aliasing and super-resolution in MRI(2019)

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk(2018)

NMDA Receptor Signaling in Oligodendrocyte Progenitors Is Not Required for Oligodendrogenesis and Myelination(2011)

Remyelination alters the pattern of myelin in the cerebral cortex(2020)

Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy(2021)

Photoreceptor layer thinning in idiopathic Parkinson's disease(2014)

Collaboration Network

No collaborations found in the dataset.

About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.