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Mohamed Mutocheluh

Clinical Microbiology

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About

Mohamed Mutocheluh is a Professor in the Department of Clinical Microbiology of the School of Medical Sciences of the Kwame Nkrumah University of Science and Technology (KNUST). He was head of department from 2020 - 2024. He served as a visiting scholar (2024/25 academicy year) at Weill Cornell Medical College in New York City, USA. His mission is to turn research into impact. As a clinical virologist and immunologist, he worked at the intersection of laboratory discovery and public health, from reducing HIV and HBV viral loads in patients to developing promising new drug candidates based on his extensive work on the antiviral type I interferon response signalling pathway. His journey has taken him from Ghana through London to New York City, forging collaborations that cross borders and disciplines. Beyond the science, he is committed to mentoring the next generation of African researchers and building the infrastructure that will make our continent a leader in global health innovation. Click on this link to learn more about his work. https://www.youtube.com/watch?v=cNdlvMiZtf4His new promising antiviral candidate drug code named LT500MM was confirmed to inhibit HIV and HBV replication in vitro during his research visit to Weill Corneil Medical College in New York City. His team had previously shown that LT500MM reduced HIV load among some people living with HIV in clinical case studies in Ghana. Since 2012 he has generated resources worth at least $600,000 USD to promote teaching and learning in KNUST. His key collaborators are the West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) and the Department of Microbial and Cellular Sciences of the University of Surrey, UK and Dr Robert Schwartz Lab at Weill Cornell Medicine in New York City.Professor Mutocheluh was born in Yendi in the Northern Region of Ghana. He attended the SakaSaka Primary School and later on spent one year at the Northern School of Business. In 1987 he won a national award to study in Cuba were attended secondary school and university.He did his national service at the Tamale Regional Hospital and later on worked there as a laboratory technologist between 1995 -1999. He joined KNUST in the year 2000 as a Medical Laboratory Technologist/teaching assistant.In 2002, he won a scholarship to the University of Nottingham UK, to study a Masters degree programme in Molecular Medical Microbiology. He went to the University of Birmingham, UK to pursue MPhil and PhD in Immunology and infection (2006 -2011).He is married to Dr Alimatu Salam and they have four beautiful daughters.

Research Summary

(inferred from publications by AI)

The researcher has focused on a diverse range of infectious diseases and medical interventions, including cervical human papillomavirus (HPV) infection and squamous intraepithelial lesions among HIV-infected and uninfected Ghanaian women, viral-associated cancers, hepatitis B virus studies, HIV/AIDS research, and more. Their work encompasses both direct medical research, such as the identification of Caspase-mediated decay of interferon regulatory factor-3 through a Kaposi Sarcoma-associated herpesvirus immunoregulatory protein, and indirect areas like cytokine signaling pathways where future experimental work may be prioritized. The researcher's broader focus includes developing new diagnostic tools for viral diseases like SARS-CoV-2 and COVID-19, as well as enhancing immunomodulation strategies to combat various health conditions. Their research also explores emerging viruses such as Kaposi’s sarcoma-associated herpesvirus and the role of cryptolepine in cancer treatment, while addressing complex issues like sexual health, respiratory infections, and infectious disease management.

Research Themes

All Papers

Epidemiology of cervical human papillomavirus (HPV) infection and squamous intraepithelial lesions (SIL) among a cohort of HIV-infected and uninfected Ghanaian women(2017)
Kaposi’s sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3(2011)
Aflatoxin B1 inhibits the type 1 interferon response pathway via STAT1 suggesting another mechanism of hepatocellular carcinoma(2017)
Low risk of SARS-CoV-2 in blood transfusion(2021)
Phased Multi-Country Seroepidemiology Study of Over 20000 Individuals In West Africa Reveals the Dynamics of SARS-CoV-2 Exposure Driven by Delta, Omicron and Omicron Waves(2023)
Prevalence and Predictors of Gestational Diabetes Mellitus in <scp>Sub‐Saharan</scp> Africa: A 10‐Year Systematic Review(2024)
Identification of Caspase-mediated Decay of Interferon Regulatory Factor-3, Exploited by a Kaposi Sarcoma-associated Herpesvirus Immunoregulatory Protein(2009)
Understanding KSHV vIRF-2-cell interactions(2011)
Knowledge and occupational hazards of barbers in the transmission of hepatitis B and C was low in Kumasi, Ghana(2015)
The prevalence of hepatitis B virus E antigen among Ghanaian blood donors(2014)
Risk factors associated with hepatitis B exposure and the reliability of five rapid kits commonly used for screening blood donors in Ghana(2014)
Sero-prevalence of Hepatitis B and C viral co-infections among HIV-1 infected ART-naïve individuals in Kumasi, Ghana(2019)
Immunosurveillance and molecular detection of hepatitis B virus infection amongst vaccinated children in the West Gonja District in Savanna Region of Ghana(2021)
Prevalence and attitude towards hepatitis B vaccination among healthcare workers in a tertiary hospital in Ghana(2020)
Cryptolepine and Nibima inhibit hepatitis B virus replication(2021)
Evaluation of inflammatory and liver injury biomarkers among drug-naive viral hepatitis B patients: A study in a referral laboratory, Ghana(2022)
Identification of dominant anti-glycan IgE responses in school children by glycan microarray(2017)
PREVALENCE AND RISK FACTORS OF VIROLOGICAL FAILURE AMONG CHILDREN ON ANTIRETROVIRAL THERAPY(2017)
Pattern and predictors of immunologic recovery in HIV infected patients(2015)
Aetiology of viral hepatitis among jaundiced patients presenting to a tertiary hospital in Ghana(2018)
Evidence of chikungunya virus infections among febrile patients at three secondary health facilities in the Ashanti and the Bono Regions of Ghana(2021)
Dengue virus exposure among blood donors in Ghana(2016)
Occurrence of Cryptosporidium Infection and Associated Risk Factors among HIV-Infected Patients Attending ART Clinics in the Central Region of Ghana(2021)
Cryptosporidium Infection and Associated Risk Factors among Cattle in the Central Region of Ghana(2021)
Cryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling(2021)
Cryptolepine consolidates its anticancer potential by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes(2021)
Cryptolepine consolidates its anticancer potential by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes(2021)
Cryptolepine consolidates its anticancer property by increasing the anti-cancer pathway genes and decreasing that of pro-cancer pathway genes(2020)
Cryptolepine, a plant-derived alkaloid, differentially regulates signal transduction pathways in human embryonic kidney (HEK293) cells(2023)
A CRYPTOLEPIS SANGUINOLENTA-BASED PREPARATION REDUCED HOSPITAL STAY AND MORTALITY OF COVID-19 PATIENTS DURING THE PANDEMI(2025)
Comparable Detection of SARS-CoV-2 in Sputum and Oropharyngeal Swab Samples of Suspected COVID-19 Patients(2022)
Aflatoxin B<sub>1</sub>: An Immunomodulator and Cancer Agent(2022)
Effect of Ochratoxin A (OTA) on the Immune System: A Systematic Review(2025)
Genetic diversity of rotavirus infection among young children with diarrhoea in the Kasena-Nankana Districts of Northern Ghana: a seasonal cross-sectional survey(2023)
Microbial pathogens associated with acute childhood diarrhoea in Kumasi, Ghana(2017)
Antifungal and Anti-Proliferative Effects of Zeolites A and X on Yeast Pathogenic and Cancer Cells <i>In Vitro</i>(2017)
Prevalence of HIV, Hepatitis B, Hepatitis C and Syphilis Infections among Patients in a Psychiatric Hospital in Ghana(2019)
Behavioural Practices Associated with Occurrence of HIV among University Students in Ghana(2015)
Molecular detection of enterovirus D68 among children with acute respiratory tract infection in Ghana(2019)
Seroprevalence of Rubella Virus, Cytomegalovirus and Herpes Simplex Virus–2 among Pregnant Women at the Komfo Anokye Teaching Hospital, Ghana(2015)
Performance of First Response® and CareStart™ Malaria Rapid Diagnostic Tests for the Detection of Plasmodium falciparum in a Tertiary Hospital in Ghana(2017)
Microbial Organisms in the Lower Respiratory Tract Associated with SARS-CoV-2 Infection: A Cross-Sectional Study in Northern Ghana(2023)
HIV co-infection and mortality pattern of purulent meningitis: A 5 year retrospective autopsy study at the Korle-Bu Teaching Hospital(2012)
Iconography : Identification of dominant anti-glycan IgE responses in school children by glycan microarray(2017)
Supplementary material : Identification of dominant anti-glycan IgE responses in school children by glycan microarray(2017)
USING A GLYCAN MICROARRAY TO IDENTIFY DOMINANT ANTI-GLYCAN IGE RESPONSES IN GHANAIAN SCHOOL-CHILDREN LIVING IN A HELMINTH-ENDEMIC AREA(2018)
The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways(2022)
Comparative Analysis of SARS-Cov-2 Detection Using Viral Swab in Viral Transport Medium Against Cotton Swab in 0.9% Normal Saline(2023)
In Vitro Cytotoxic Activity of Five Ghanaian Plants on Human Cancer Cell Lines(2024)
In vitro cytotoxic activity of five Ghanaian plants on human cancer cell lines(2024)

Collaboration Network

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.