Lawrence Sheringham Borquaye

Chemistry

About

Lawrence Sheringham Borquaye is an alumni of St. Mary’s Seminary Senior High School (SMASCO), Lolobi – VR, Ghana where he graduated in 2000. He received his B. Sc. in Chemistry from the University of Cape Coast, Ghana in 2006, working with Dr. Victor Y. Atsu - Barko in investigating the mosquito repellency properties of the leaves of Hyptis suaveleons. He proceeded to the University of Massachusetts Amherst, USA and graduated in 2013 with a Ph.D. in Chemistry working under the mentorship of Professor Nathan A. Schnarr in developing new tools for engineering polyketide synthases (PKSs), the gigantic biosynthetic machinery responsible for the assembly of the class of natural product called polyketides. This work was partly supported by the UMASS Amherst Chemistry-Biology Interface Trainee Fellowship. After graduate studies, Lawrence joined the Kwame Nkrumah University of Science and Technology (KNUST), Kumasi where he is a lecturer in the Department of Chemistry. He also doubles as the Assistant Laboratory Manager of the KNUST Central Laboratory, a state-of-the-art research facility that is home to modern analytical instruments for research in the basic and applied sciences. The research works of Lawrence Sheringham Borquaye has been funded by research grants from the International Foundation for Science, the Building Stronger Universities II (BSU II) project which is a DANIDA funded program between KNUST and some Danish universities, The World Academy of Sciences (TWAS) and the KNUST Research Fund (KReF).Lawrence has supervised thesis at the undergraduate, Master's and Doctoral levels.

Research Summary

(inferred from publications by AI)

The researcher's research focuses on integrating computational methods into drug discovery and development, particularly addressing public health issues such as infectious diseases, toxic environments, traditional medicine, and plant biochemistry. Their work encompasses a wide range of topics, including computational chemistry, mathematical modeling, molecular dynamics simulations, toxicity assessment, and the application of advanced analytical techniques across various biological systems. The researcher's contributions span themes like heavy metals, traditional Ghanaian medicines, malaria research, traditional use of Annonaceae plants, merozotetunia, traditional herbal extracts, toxic metal residues, plant biochemistry, enzymatic studies, marine sponges, organometallic compounds, phytochemistry, ginger and zingiberaceae research, Leishmania control, mathematical modeling for toxicity, mine management, water quality assessment, child nutrition, biofuel production, plant biochemistry, algal biology, chemical synthesis, genetic and molecular insights into infectious diseases, distributed computing systems, mycobacterium research, and genomics. Their research integrates computational approaches with biological and chemical methods to develop innovative solutions for public health challenges.

Research Themes

All (100 Papers)

Physical Sciences (38 Papers)

Life Sciences (47 Papers)

Health Sciences (15 Papers)

All Papers

Applications of molecular docking in natural products-based drug discovery(2023)

Allosteric Modulation of the Main Protease (MPro) of SARS-CoV-2 by Casticin—Insights from Molecular Dynamics Simulations(2022)

Distribution of heavy metals in soils from abandoned dump sites in Kumasi, Ghana(2020)

Urbanizing with or without nature: pollution effects of human activities on water quality of major rivers that drain the Kumasi Metropolis of Ghana(2021)

Distribution and ecological risks of toxic metals in the topsoils in the Kumasi metropolis, Ghana(2017)

Accumulation and bioaccessibility of toxic metals in root tubers and soils from gold mining and farming communities in the Ashanti region of Ghana(2020)

Human health risk assessment of potentially toxic elements in soil and air particulate matter of automobile hub environments in Kumasi, Ghana(2023)

Distribution and in-vitro bioaccessibility of potentially toxic metals in surface soils from a mining and a non-mining community in Ghana: implications for human health(2023)

Health risks of potentially toxic metals in cereal-based breakfast meals in the Kumasi Metropolis, Ghana(2023)

Distribution, bioaccessibility and human health risks of toxic metals in peri-urban topsoils of the Kumasi Metropolis(2021)

Source Apportionment of Potentially Toxic Elements in Topsoils Across Some Mining-Impacted Communities in Ghana Using the Positive Matrix Factorization Model(2025)

Chemical Composition, Total Phenolic Content, and Antioxidant Activities of the Essential Oils of the Leaves and Fruit Pulp ofAnnona muricataL. (Soursop) from Ghana(2019)

Essential Oil Emulsions from Xylopia Villosa and Hyparrhena Rufa as Potent Antimicrobial and Antibiofilm Agents(2025)

Chemical characterization, biological activities, and molecular docking studies of essential oils from Annona reticulata L (Annonaceae)(2025)

Heavy metal contents of some medicinal herbs from Kumasi, Ghana(2016)

Alkaloids from Cryptolepis sanguinolenta as Potential Inhibitors of SARS‐CoV‐2 Viral Proteins: An In Silico Study(2020)

An In Silico Study of the Interactions of Alkaloids from Cryptolepis sanguinolenta with Plasmodium falciparum Dihydrofolate Reductase and Dihydroorotate Dehydrogenase(2022)

A CRYPTOLEPIS SANGUINOLENTA-BASED PREPARATION REDUCED HOSPITAL STAY AND MORTALITY OF COVID-19 PATIENTS DURING THE PANDEMI(2025)

Occurrence of Antibiotics and Antibiotic-Resistant Bacteria in Landfill Sites in Kumasi, Ghana(2019)

Antibiotic and analgesic residues in the environment – Occurrence and ecological risk study from the Sunyani municipality, Ghana(2022)

Occurrence of Pharmaceutical Residues and Antibiotic-Resistant Bacteria in Water and Sediments from Major Reservoirs (Owabi and Barekese Dams) in Ghana(2022)

Disposal of Unused and Expired Medicines within the Sunyani Municipality of Ghana: A Cross‐Sectional Survey(2022)

Veterinary antibiotics in dairy products from Kumasi, Ghana(2017)

Occurrence and Ecological Risk Assessment of Pharmaceutical Residues in Effluents from Pharmaceutical Manufacturing Facilities in Kumasi, Ghana(2023)

Ecological risk assessment of selected pharmaceuticals in major rivers within Kumasi, Ghana(2024)

Environmental impact of pharmaceutical contaminants in dumpsites: a study from Ejisu-Juaben municipality, Ghana(2024)

Pharmaceutical residues in environment matrices in the Sekondi-Takoradi metropolis of Ghana present potential ecotoxicological risks(2025)

Occurrence and ecological risk assessment of commonly used pharmaceuticals in water and soil of Sefwi Wiawso, Ghana(2025)

Pharmaceutical Waste Disposal: A Cross‐Sectional Survey of Disposal Practices and Awareness in Sefwi Wiawso Municipality, Ghana(2025)

Antimalarial Efficacy and Toxicological Assessment of Extracts of Some Ghanaian Medicinal Plants(2019)

Computational elucidation of Plasmodium falciparum enoyl-ACP reductase inhibition by Salacia debilis compounds: adaptive ligand binding drives antimalarial activity(2025)

Human Risk Assessment of Organochlorine Pesticide Residues in Vegetables from Kumasi, Ghana(2018)

Pesticide Residues in Honey from the Major Honey Producing Forest Belts in Ghana(2017)

Antimicrobial and antioxidant properties of the crude peptide extracts of Galatea paradoxa and Patella rustica(2015)

Anti-inflammatory and anti-oxidant activities of ethanolic extracts of Tamarindus indica L. (Fabaceae)(2020)

Anti-inflammatory and antioxidant activities of extracts ofReissantia indica, Cissus cornifoliaandGrosseria vignei(2020)

Antimalarial, Antioxidant, and Toxicological Evaluation of Extracts of Celtis africana, Grosseria vignei, Physalis micrantha, and Stachytarpheta angustifolia(2021)

Chemical Composition, Antioxidant, and Antimicrobial Activities of the Leaf and Fruit Essential Oils of the West African Plum, Vitex doniana(2023)

In Vivo Antiplasmodial Activity and Toxicological Analyses of the Ethanolic Leaf and Twig Extract of Faurea speciosa Welw. (Proteaceae)(2021)

In vitro antileishmanial activity and molecular docking studies of lupeol and monostearin, isolated from Parkia biglobosa(2022)

Antiplasmodial potential and safety evaluation of the ethanolic stem bark extract of Distemonanthus benthamianus Baill. (Leguminosae)(2021)

Peptide Extract from Olivancillaria hiatula Exhibits Broad-Spectrum Antibacterial Activity(2018)

N-benzylimidazoles as potential antimicrobial and antibiofilm agents – syntheses, bioactivity and molecular docking studies(2022)

Computer-aided design of proline-rich antimicrobial peptides based on the chemophysical properties of a peptide isolated from Olivancillaria hiatula(2022)

De novo peptides as potential antimicrobial agents(2023)

Molecular insights into the differential membrane targeting of maximin 1 in prokaryotic and eukaryotic cells(2023)

Peptide Extract from Red Kidney Beans, Phaseolus vulgaris (Fabaceae), Shows Promising Antimicrobial, Antibiofilm, and Quorum Sensing Inhibitory Effects(2024)

Nutritional and anti-nutrient profiles of some Ghanaian spices(2017)

Risk Of Human Dietary Exposure To Organochlorine Pesticide Residues In Fruits From Ghana(2018)

Chemical Composition and Biological Activities of the Essential Oils of Chrysophyllum albidum G. Don (African Star Apple)(2021)

Chemical Characterization, Antioxidant, Antimicrobial, and Antibiofilm Activities of Essential Oils of Plumeria alba (Forget-Me-Not)(2023)

Essential Oils from the Fruits and Leaves of Spondias mombin Linn.: Chemical Composition, Biological Activity, and Molecular Docking Study(2022)

Essential Oils from Averrhoa carambola L. (Oxalidaceae): Chemical Composition, Antioxidant, Antimicrobial and Anti-biofilm Potential(2021)

Ethanolic leaf extract from Strophanthus gratus (Hook.) Franch. (Apocynaceae) exhibits anti-inflammatory and antioxidant activities(2019)

Antioxidant, antimicrobial, and antibiofilm properties of essential oils extracted from Dialium guineense(2023)

Peptide Mix from Olivancillaria hiatula Interferes with Cell-to-Cell Communication in Pseudomonas aeruginosa(2019)

Computational Studies Provide a Molecular Basis for the Quorum Sensing Inhibitory Action of Compounds from Dioon spinulosum Dyer Ex Eichler(2023)

Marine-Derived Furanones Targeting Quorum-Sensing Receptors in Pseudomonas aeruginosa: Molecular Insights and Potential Mechanisms of Inhibition(2024)

Targeting Quorum Sensing in Pseudomonas aeruginosa Using Marine‐Derived Metabolites—An In Silico Approach(2024)

N-alkylimidazole derivatives as potential inhibitors of quorum sensing in Pseudomonas aeruginosa(2022)

Veterinary Drug Residues in Beef, Chicken, and Egg from Ghana(2021)

Human exposure to mercury in the atmosphere and soils in Konongo: an age-old mining centre in the Ashanti Region of Ghana(2022)

Receptor modeling, ecological risks, and human health impacts of mercury in some Ghanaian topsoils due to mining and commercial activities(2025)

The Amaryllidaceae alkaloid, montanine, is a potential inhibitor of the Trypanosoma cruzi trans-sialidase enzyme(2023)

Antimicrobial resistance modifying effects and molecular docking studies of Affinine, derived from Tabernaemontana crassa(2024)

Antimicrobial and antioxidant activities of ethyl acetate and methanol extracts ofLittorina littoreaandGalatea paradoxa(2016)

Anti-inflammatory activities of extracts fromOliva sp., Patella rustica, andLittorina littoreacollected from Ghana’s coastal shorelines(2017)

Antimicrobial properties of metal piperidine dithiocarbamate complexes against Staphylococcus aureus and Candida albicans(2021)

Anti-inflammatory and antioxidant activities of the root and bark extracts of Vitex grandifolia (Verbanaceae)(2020)

Biological Efficacy and Toxicological Evaluation of Ethanolic Extract of Cassia nodosa Buch.-Ham. (Leguminosae)(2020)

Assessment of some quality parameters and chemometric-assisted FTIR spectral analysis of commercial powdered ginger products on the Ghanaian market(2022)

Quality Assessment and Chemometric-Assisted FTIR Spectral Analysis of Commercial Powdered Ginger Products on the Ghanaian Market(2021)

Computational studies on potential small molecule inhibitors of Leishmania pteridine reductase 1(2023)

In silico identification of α-bisabolol and letestuianin C as potential inhibitors of Trypanosoma brucei trypanothione reductase(2023)

Antileishmanial natural products as potential inhibitors of the Leishmania pteridine reductase: insights from molecular docking and molecular dynamics simulations(2024)

Molecular insights into the inhibition of Leishmania donovani O-acetylserine sulfhydrylase by cyclopropane carboxylic acid derivatives: a computational study(2024)

Optimization of hydrolases production from cassava peels by Trametes polyzona BKW001(2021)

Clinical characteristics of external bacterial ocular and periocular infections and their antimicrobial treatment patterns among a Ghanaian ophthalmic population(2022)

Clinical Characteristics of External Ocular and Periocular Infections and Their Antimicrobial Treatment Patterns Among a Ghanaian Ophthalmic Population; A Multicenter Study(2022)

Oplodiol and nitidine as potential inhibitors of Plasmodium falciparum dihydrofolate reductase: insights from a computational study(2023)

Synthesis, molecular docking studies and ADME prediction of some new triazoles as potential antimalarial agents(2021)

Spatial distribution, bioaccessibility, and human health implications of potentially toxic elements in mining-impacted topsoils in Obuasi Municipality of Ghana(2024)

Assessment of the quality of the Owabi reservoir and its tributaries(2018)

Patterns in protein consumption in Ghanaian cities(2020)

Descriptive analysis of pharmaceutical disposal practices in Sekondi-Takoradi: implications for environmental and public health safety in Ghana(2025)

Conversion of cassava peels into bioethanol using the OSTEP approach(2022)

Antimalarial compounds from the climbing stems of salacia debilis(2023)

ORGANIC CHEMISTRY | RESEARCH ARTICLE Antimicrobial and antioxidant activities of ethyl acetate and methanol extracts of Littorina littorea and Galatea paradoxa(2016)

Abstract 2266 Amaryllidaceae Alkaloids as Potential Inhibitors of the Trypanosoma cruzi Trans-sialidase Enzyme: Unique Insights from Computational Studies(2024)

Optimization of Hydrolase Production (Dataset).pdf(2020)

Optimization of Hydrolases Production (Dataset).pdf(2020)

Crude Alkaloids form Phyllanthus fraternus, Webster: Antibacterial, Time-Kill Kinetics and Resistance Modulation Studies(2025)

Crude alkaloids from Phyllanthus fraternus, Webster: Antibacterial, time-kill kinetics and resistance modulation studies(2025)

Synergistic action of phytoconstituents drives the anthelmintic potential of Croton penduliflorus stem bark extracts(2025)

In Silico Investigation of Phytochemicals From Clinically Tested Herbal Extracts as Potential Dihydrofolate Reductase Inhibitors for Buruli Ulcer(2025)

Pharmacogenomics in Orofacial Clefts Care: Insights from Whole-Genome Sequencing of Case-Parents Trios(2025)

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.