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Kwadwo Opoku

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Research Summary

(inferred from publications by AI)

The researcher has conducted extensive work across diverse themes, focusing on the integration of hydrocarbon-stapled peptide helices in biochemical processes. Their research encompasses chemical synthesis for cellular functions, such as the uptake and GTPase signaling roles, inhibition of oncogenic KRAS, and their involvement in autophagy-mediated neurodegeneration. Additionally, they have contributed to understanding the role of RNA interference pathways, including the function of proteins like TRiC/CCT. Their work also extends to diabetes treatment with specific peptide agonists and heat shock protein research for cell division.

Research Themes

All Papers

Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices(2016)
Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices(2015)
Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases(2019)
Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration(2018)
The YΦ motif defines the structure-activity relationships of human 20S proteasome activators(2022)
The YΦ Motif Defines the Structure-Activity Relationships of Human 20S Proteasome Activators(2021)
Abstract 4611: Multimodal activation of apoptosis by a hydrocarbon-stapled PUMA BH3 helix.(2013)
Human 20S proteasome bound to an engineered 11S (PA26) activator(2020)
Abstract 2597: Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices(2014)
Abstract B41: Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices(2014)
Redefining HbYX-dependent activation of the human 20S proteasome(2020)
Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection(2014)
Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease(2018)
Author Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease(2020)
Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease(2018)
Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease(2020)
Multimodal Interaction with BCL-2 Family Proteins Underlies the Proapoptotic Activity of PUMA BH3(2013)
Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor(2020)
A hierarchical assembly pathway directs the unique subunit arrangement of TRiC/CCT(2023)
A structural vista of phosducin-like PhLP2A-chaperonin TRiC cooperation during the ATP-driven folding cycle(2024)

Collaboration Network

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.