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James Oppong-Kyekyeku

Pharmaceutical Chemistry

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About

Dr James Oppong-Kyekyeku graduated from the Kwame Nkrumah University of Science and Technology with B.Pharm(Pharmacy), M.Phil. and PhD (Pharmaceutical Chemistry). He had his secondary education at Opoku Ware School in Kumasi. He has been a member of the Pharmaceutical Society of Ghana since 2009. He is a DAAD alumnus.

Research Summary

(inferred from publications by AI)

The researcher has conducted extensive work on bioactive compounds, integrating microbial natural products and phytochemicals into their health and biomedical research. Their work spans diverse domains, including immune modulation, inflammatory bowel disease, metabolic disorders, and Zebra fish biomedical applications. Additionally, they have made significant contributions to analytical methods in this field, focusing on bioactivity studies of key compounds across various plant families.

Research Themes

All Papers

Resistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from <i>Plumbago zeylanica</i> Linn(2019)
Investigation of Acid-Base Indicator Property of Plumbagin from<i>Plumbago zeylanica</i>Linn(2019)
Antibacterial secondary metabolites from an endophytic fungus, Fusarium solani JK10(2017)
Prenylated 2-arylbenzofuran derivatives with potent antioxidant properties from Chlorophora regia (Moraceae)(2015)
Acetic acid‐induced colitis modulating potential of total crude alkaloidal extract of <i>Picralima nitida</i> seeds in rats(2023)
The crude alkaloidal extract of Picralima nitida seeds alleviates TNBS-induced inflammatory bowel disease through reduced serum expression of TNF-α, IL-1β and p38 MAPK(2024)
Attenuation of Anxiety Behaviours by Xylopic Acid in Mice and Zebrafish Models of Anxiety Disorder(2018)
Wound Healing Activity of Total Alkaloidal Extract of the Root Bark of Alstonia boonei (Apocynacea)(2014)
Analgesic Effects of an Ethanol Extract of the Fruits of Xylopia aethiopica and Xylopic Acid in Murine Models of Pain: Possible Mechanism(s)(2013)
Effects of an ethanol extract and the diterpene, xylopic acid, of <i>Xylopia aethiopica</i> fruits in murine models of musculoskeletal pain(2016)
MALDI–HRMS imaging and HPLC–HRESI–MS<sup><i>n</i></sup> characterisation of kaurane diterpenes in the fruits of <scp><i>Xylopia aethiopica</i></scp> (Dunal) A. Rich (Annonaceae)(2019)
Characterization and HPLC Quantification of Xylopic Acid in the Dried Fruits of Xylopia Aethiopica(2010)
CHARACTERIZATION AND HPLC QUANTIFICATION OF PIPERINE ISOLATED FROM PIPER GUINEENSE (Fam. PIPERACEAE)(2013)
Regulation of Nrf2 and NF-κB activities may contribute to the anti-inflammatory mechanism of xylopic acid(2022)
Development and Validation of an Ion-Pair HPLC-UV Method for the Quantitation of Quinoline and Indoloquinoline Alkaloids in Herbal and Pharmaceutical Antimalarial Formulations(2022)
Geraniin attenuates Naloxone-Precipitated Morphine Withdrawal and Morphine-Induced Tolerance in Mice(2017)
Antitrypanosomal and Anthelminthic Properties of Ethanol Extracts of Carica papaya Linn. and Ceiba pentandra (L) Gaertn.(2022)
Inflammation Modulating Activity of the Hydroethanol Stem Bark Extract of Bombax costatum in Murine Models(2022)
LC–HRESI–MS/MS Profiling of Flavonoids from Chlorophora regia (Moraceae)(2017)
Quality Control and Anti-Inflammatory Activity of the Stem Bark of Chlorophora regia A. Chev. (Moraceae)(2021)
Chromatographic method development for the simultaneous assay of pseudoephedrine hydrochloride and chlorphenamine maleate in oral dosage formulations(2022)
HPLC-HRESI-MSn Characterization of Polyphenolic Compounds in the Stem Bark of Chlorophora regia A. Chev (Moraceae)(2022)
Flash Talk 1 “Quality control of extracts and herbal products containing Anthocleista nobilis G. Don. via a validated RP-HPLC method”(2022)
Development and Validation of an RP-HPLC Method for the Quantitative Analysis of Triclosan in Human Urine(2023)
CCDC 1487779: Experimental Crystal Structure Determination(2017)
Phytochemical constituents from corn silk and antimicrobial activity of the isolates(2024)

Collaboration Network

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.