Christopher Larbie

Biochemistry and Biotechnology

About

Christopher Larbie, PhD is a Senior Lecturer in the Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi and the Principal Investigator for the HepatoRenal Research Group. He was also a Fulbright Scholar (2018/19) at the National Center for Natural Products Research at the University of Mississippi, USA. Dr Larbie’s research group focuses on the toxicological and pharmacological evaluation of medical herbs, spices, vegetables and some ornamental for the management of liver and kidney diseases as well as diabetes, hypertension and cancers. His team uses both cell lines and whole organisms and employ techniques including chromatography, biochemical and haematological assessment, histopathology and immunohistochemistry. Check my ResearchGate (https://www.researchgate.net/profile/Christopher_Larbie) and ORCID (https://orcid.org/0000-0003-4927-4419) profile

Research Summary

(inferred from publications by AI)

The researcher has conducted extensive work across diverse areas of health and natural sciences, with a focus on metabolic dysfunction, nutritional studies, toxicological effects, and bioactive plant extracts. Their research integrates comprehensive approaches to address various human health challenges, including metabolic disorders, nutritional deficiencies, hepatotoxicity, and phytochemical analysis. Through their publications, the researcher has contributed significantly to understanding the roles of plants and extracts in disease resistance and management, as well as the impact of toxicants on cellular health. These studies underscore the importance of a holistic approach in improving personal and population-level health outcomes, emphasizing the synergy between metabolic function, nutritional intake, and the application of natural products for therapeutic effects.

Research Themes

All Papers

Prevalence and Determinants of Diabetic Foot Ulcers and Lower Extremity Amputations in Three Selected Tertiary Hospitals in Ghana(2019)

Pica practice among pregnant women in the Kumasi metropolis of Ghana(2010)

Evaluation of hepatoprotective effect of aqueous extract of Annona muricata (Linn.) leaf against carbon tetrachloride and acetaminophen-induced liver damage(2012)

Modulation of Oxidative Stress and Inflammatory Cytokines as Therapeutic Mechanisms ofOcimum americanumL Extract in Carbon Tetrachloride and Acetaminophen-Induced Toxicity in Rats(2020)

Evaluation of the Acute Hepatoprotective Potential of Hydroethanolic Extract of Duranta erecta L. Parts(2020)

Hura crepitans stem bark extract: A potential remedy to sub-acute liver damage(2021)

Toxicity of the Hydroethanolic Leaves Extract of Duranta erecta L. in Rat Models(2020)

Ameliorative effect of extract of Tecoma stans (L.) Juss. ex kunth leaves against CCl4 - and acetaminophen—induced liver damage in rats(2020)

Extracts of Hura crepitans L. stem bark attenuate liver injury and inflammation induced by CCl4 in rats(2020)

Acalypha wilkesiana ‘inferno’ hydroethanolic leaf extract has protective effect on carbon tetrachloride-induced subacute toxicity in animals(2020)

Hepatoprotective Activity of Plant Extracts in Non-Human Models: The Toxicants Solvents and Diseased Models-A Review(2023)

Pericopsis laxiflora (Baker) stem bark extract is protective against carbon tetrachloride-induced acute liver damage by modulation of oxidative stress and inflammation(2024)

Hydroethanolic Extracts of Ficus pumila Linn. Is Protective against Gentamicin-Induced Kidney Damage in Rats(2018)

Hepatoprotective Properties of Aqueous and Ethanolic Stem Bark Extracts of Hura crepitans Linn. Against CCl 4 − Induced Acute Liver Damage in Rats(2019)

Toxicity of the Hydroethanolic Leaves Extract of Duranta erecta L. in Rat Models(2020)

Hydroethanolic extract and fractions of Pericopsis laxiflora stem bark protect against liver injury in Rat(2024)

Medicinal Plants and Their Finished Marketed Herbal Products Used for Treatment of Liver Diseases in Ghana; A Field Survey and Review(2024)

Anti-Inflammatory and Antioxidant Potential of Ageratum conyzoides Ethanol Extract Against Carbon Tetrachloride-Induced Renal Toxicity in Rats(2025)

Duranta erecta L. extracts exert hepatoprotective effect on CCl4-induced toxicity via inactivating NF-kB pathway(2025)

Phytochemical, Antimicrobial, and Antioxidant Profiles of Duranta erecta L. Parts(2019)

Phytochemical and Safety Evaluation of Hydroethanolic Leaf Extract of Tecoma stans (L.) Juss. ex Kunth(2019)

Ethnobotany, Phytochemistry and Pharmacology of Pericopsis laxiflora (Baker) Meeuwen (Leguminosae) – A Review(2021)

Safety evaluation of hydroethanolic fruit extracts of Duranta erecta Linn(2022)

Prevalence and Predictors of Gestational Diabetes Mellitus in <scp>Sub‐Saharan</scp> Africa: A 10‐Year Systematic Review(2024)

Assessment of the antioxidant and nutritive profile of the leaves and berries of Solanum nigrum and Solanum torvum Swart(2024)

Assessment of the Antioxidant and Nutritive Profile of the Leaves and Berries of Solanum Nigrum and Solanum Torvum Swart(2024)

Hydroethanolic Leaves Extract of Amaranthus Cruentus Protects Against Lead-Induced Hepatorenal Toxicity in Rats(2024)

Tetrapleura tetraptera of Ghanaian Origin: Phytochemistry, Antioxidant and Antimicrobial Activity of Extracts of Plant Parts(2020)

In vitro Antioxidant and Anticancer Properties of Hydroethanolic Extracts and Fractions of Ageratum conyzoides(2015)

Extracts of Ageratum Conyzoides L. Protects against Carbon Tetrachloride – Induced Toxicity in Rats through Inhibiting Oxidative Stress(2019)

Tetrapleura tetraptera of Ghanaian Origin: Phytochemistry, Antioxidant and Antimicrobial Activity of Extracts of Plant Parts(2020)

Sensory evaluation and chemical composition of Solanum nigrum and Solanum torvum herbal tea and spice(2024)

Palm Weevil Larvae (Rhynchophorus phoenicis Fabricius) and Orange-Fleshed Sweet Potato-Enriched Biscuits Improved Nutritional Status in Female Wistar Albino Rats(2020)

Proximate composition and basic phytochemical assessment of two common varieties of Terminalia catappa (Indian Almond).(2009)

Extracts of Codiaeum variegatum (L.) A. Juss is Cytotoxic on Human Leukemic, Breast and Prostate Cancer Cell Lines(2016)

Hepatoprotective Potential of Hura crepitans L.: A Review of Ethnomedical, Phytochemical and Pharmacological Studies(2020)

Anti-diabetic and hypolipidaemic effect of botanicals: a review of medicinal weeds on KNUST campus, Kumasi(2014)

Anti-diabetic effect of aqueous fruit extract of Borassus aethiopum (Mart.) in alloxan-induced diabetic rats(2016)

Antioxidant, anti-inflammatory and cytotoxicity properties of medicinal plants used for producing herbal products against hepatic diseases in Ghana(2025)

Phytochemical, Antioxidant and Safety Evaluation of Hura crepitans (L.) Stem Bark Hydroethanolic Extract in Animals(2020)

Status of Some Antioxidant Micronutrient and Pregnancy Outcomes in Ghanaian Adolescents Attending Antenatal Clinic in Urban (Suntreso) and Rural (Mampong) Hospitals(2017)

Geophagia, nutrition and health of women with pregnancy-induced hypertension(2018)

The Association between Micronutrients Levels and Gestational Diabetes: A Cross Sectional Study in Ashanti Region(2018)

Phytochemicals isolated from the root bark of Sarcocephalus latifolius (Sm.) E.A.Bruce(2019)

Griffonia simplicifolia (DC.) Baill. attenuates gentamicin and cisplatin-induced nephrotoxicty in rats(2019)

Biochemical and anti-inflammatory effect of Ocimum americanum Linn. extracts on gentamicin- and cisplatin-induced nephrotoxicity in rats(2020)

Nephroprotective Activity of Dialium guineense Aqueous Extract Against Cisplatin-Induced Kidney Damage in Rats(2024)

Acalypha wilkesiana ‘Inferno’ Is Nephroprotective Against Gentamicin and Cisplatin: Biochemical, Histological and Immunohistochemical Evidence(2020)

Protective effect of hydroethanolic leaves extract of Solanum macrocarpon on Cisplatin-induced kidney injury in rats(2024)

Luteolin normalizes blood pressure via its antioxidant activity and down-regulation of renal Angiotensin II receptor and Mineralocorticoid receptor expressions in rats co-exposed to Diclofenac and sodium fluoride(2022)

Anti-proliferative effect of Ficus pumila Linn. on human leukemic cell lines(2015)

Heavy metal contamination of Cabbage Sections from different farms in Ghana(2014)

Phytochemical Constituents of Flour and Composite Bread from African Palmyra (Borassus aethiopum) Fruit from Ghana(2018)

Review of: "Toxicological evaluation of aqueous extracts of Clematis hirsuta and Rhamnus prinoides"(2023)

Pericopsis laxiflora (Baker) Stem bark extract ameliorates acute Lead-induced hepatotoxicity: Modulation of Oxidative Stress and Inflammatory Pathways(2024)

Methoxy-flavones identified from Ageratum conyzoides induce capase -3 and -7 activations in Jurkat cells(2017)

Borassus aethiopum Fruit Pulp Extract has Antimicrobial Activity on Selected Clinical Microbial Strains(2018)

Extract of Fermented and Non-Fermented Seeds of Parkia Biglobosa Attenuates Hyperglycaemia and Related Nephropathy in Type 2 Diabetes Mellitus Animals.(2022)

Nutritional Composition and Acceptability of Baobab Pulp–Fortified Pearl Millet Instant Beverage Powder Among Adolescent Girls(2025)

Evaluating circulating soluble markers of endothelial dysfunction and risk factors associated with PE: A multicentre longitudinal case control study in northern Ghana(2023)

Phytochemical Constituents and Biological Activity of Fractions of Stem and Leaves of Acalypha inferno(2018)

Levels of Pathogens, Heavy Metals, Essential Ions and Organochlorides in Herbal Medicines and Plant Species Used for Hepatic Diseases in Ghana(2024)

Anti-proliferative Effect of Isoflavones Isolated from Soybean and Soymilk Powder on Lymphoma (DG 75) and Leukemia (CEM) Cell Lines(2015)

In vitro antioxidant and anticancer properties of hydroethanolic extracts, fractions and novel flavones of Ageratum conyzoides leaves(2016)

Hepatoprotective Effects of Tetrapleura tetraptera (Schum. & Thonn.) Taub. Stem Bark Extracts in Drug-induced Toxicities in Rats(2023)

Exploiting senescence as a therapeutic target in osteoarthritis(2024)

Prevalence, Risk Factors and Predictors of Diabetes-related Sexual Dysfunction(2016)

Body mass index and its effect on rate of hospital visits of staff of Kwame Nkrumah University of Science and Technology, Kumasi(2014)

Evaluation of the antioxidant activities of some wild edible indigenous Ghanaian mushrooms(2018)

Dietary Pattern and Prevalence of Metabolic Syndrome in Hypertensive Outpatients and Associated Effect on Target Organ Damage(2024)

Nutritional Intervention in Children Undergoing Chemotherapy for Cancer(2018)

Effects of chemotherapy and disease burden on the nutritional status of patients undergoing treatment for burkitt’s lymphoma(2015)

The Haematology and Serum Biochemistry of Traditional Textile Dyers in Ntonso, Kumasi were Affected by Exposure to Synthetic Textile Dyes(2023)

Health and Toxicity Effects of Solanum torvum and Solanum nigrum Berries Extract on Rats(2024)

Prevalence of the Genetic Mutation CYP2C8*5 in Selected Ethnic Groups in Southern Ghana(2016)

Prevalence of Hypertension and Prognosis of Associated Dysfunction on Specific Organ Function among Ghanaian Adolescent Students(2018)

Association of metabolic syndrome with the risk of developing liver disease in chronic hepatitis B patients(2019)

Assessing the prevalence and risk factors of neural tube defects at the Komfo Anokye Teaching Hospital, Kumasi(2021)

Methoxy‐flavones Identified from Ageratum conyzoides Induce Caspase ‐3 and ‐7 Activations in Jurkat Cells(2019)

Phytochemical constituents and biological activities of Erythrina indica(2011)

Luteolin Reduces Blood Pressure via Down-regulation of Renal Angiotensin II Receptor and Mineralocorticoid Receptor Expressions in Rats Co-exposed to Diclofenac and Sodium Fluoride(2021)

Comparative Analyses of the Antimicrobial, Antioxidant, and Phytochemical Composition of Two Species of Moringa in Ghana(2023)

Antidiabetic and Antioxidant Potential of Detarium microcarpum and Zanthoxylum zanthoxyloides and Combined Extract Efficacy in Rats(2024)

Analysing the Composition of Commercial Turmeric Powder: Assessing Contaminants and Its Impacts Curcumin and Water-soluble Vitamins Levels(2024)

Pearl millet instant beverage powder enriched with baobab pulp to improve iron and anaemia status of adolescent girls in rural Ghana: a study protocol for a cluster randomised controlled trial(2024)

Assessment of the Nutritional and Phytochemical Composition in Beta Vulgaris Bulb, Stalk and Leaves Powder(2025)

Prevalence of Babesia and associated haematological changes in pigs in the Ejisu and Juaben Municipalities, Ghana(2025)

Assessment of the nutritional and phytochemical composition in Beta vulgaris bulb, stalk and leaves powder(2025)

Collaboration Network

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.