Charles Ansah

Pharmacology

About

I have considerable experience as a university professor and administrator. I have been a university administrator as a Head of Department, Dean and acted as Provost on several occasions. I have also served as a former Pro Vice-Chancellor. I have served on several non-statutory and statutory committees of KNUST including the Academic Board. I have been in attendance at the Governing Council of KNUST as a Pro Vice-Chancellor. I have served as an assessor of the defunct NAB for new programmes at both public and private universities.I have travelled extensively to other universities and I am familiar with the processes and procedures in university management and how universities should brace themselves to face future challenges in the face of dwindling public funding.I have also served on several state boards including the Agogo Presbyterian College of Education, Pharmacy Council, Food and Drugs Authority and the Centre for Plant Medicine Research, Mampong Akuapem. Presently, I am presently a member of the Ministry of Health Research Committee on Herbal medicines for the possible management of Covid-19 and serve on the Ad Hoc committee charged to develop basic procedures for assessing the efficacy and safety of herbal products. I am an astute researcher in the area of toxicology, pharmacy, pharmacology and herbal medicine and have published extensively in reputable journals in the area of toxicology and pharmacology Am also a member of the KNUST research team on Covid-19. Currently, I serve as an Expert/ Consultant of traditional medicine for the West African Health Organization (WAHO).

Research Summary

(inferred from publications by AI)

The researcher has conducted extensive work in pharmacological studies focusing on gastrointestinal diseases, particularly related to helicobacter pylori, inflammatory bowel disease, alkaloid synthesis, toxicological effects of natural compounds, and plant-based extracts. Their findings include the development of novel antiviral agents, insights into gut microbiota-herbal interactions, exploration of alkaloid bioactivity, understanding of toxicity mechanisms in mammals, and contributions to reproductive health interventions.

Research Themes

All Papers

In VivoModels Used for Evaluation of Potential Antigastroduodenal Ulcer Agents(2013)

Isolation of Helicobacter pylori from Gastric Biopsy of Dyspeptic Patients in Ghana and In Vitro Preliminary Assessment of the Effect of Dissotis rotundifolia Extract on Its Growth(2018)

In vivo inhibition of gastric acid secretions and H+/K+- ATPase activity, and enhancement of mucin activity by Dissotis rotundifolia plant extract(2022)

Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract ofCordia vigneiLeaves through Reduced Serum Levels of TNF-αand IL-6(2020)

In vitro genotoxicity of the West African anti-malarial herbal Cryptolepis sanguinolenta and its major alkaloid cryptolepine(2004)

A review of the anticancer potential of the antimalarial herbal cryptolepis sanguinolenta and its major alkaloid cryptolepine.(2013)

In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine(2017)

Synergistic anti-malarial action of cryptolepine and artemisinins(2016)

Cryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling(2021)

Toxicological assessment of Cryptolepis sanguinolenta for possible use in veterinary medicine(2009)

Cryptolepine, the Main Alkaloid of the Antimalarial Cryptolepis sanguinolenta (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos(2019)

Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats(2017)

Toxicological Evaluation of the Anti-Malarial Herb Cryptolepis sanguinolenta in Rodents(2008)

Reproductive and Developmental Toxicity of Cryptolepis sanguinolenta in Mice(2010)

Cryptolepine, the major alkaloid of Cryptolepis sanguinolenta (Lindl.) Schlechter (Apocynaceae), attenuates early and late-phase symptoms of asthma(2020)

The Mechanism of Cryptolepine-Induced Cell Death(2008)

Cryptolepine Provokes Changes in the Expression of Cell Cycle Proteins in Growing Cells(2009)

Erratum to: Synergistic anti-malarial action of cryptolepine and artemisinins(2016)

In vitro antimalarial interaction and transmission-blocking activity of cryptolepine(2016)

Reactive oxygen species is associated with cryptolepine cytotoxicity(2005)

The molecular toxicology of Cryptolepis sanguinolenta, a West African anti-malarial herbal medicine.(2004)

(2013)

Antibiotic use during pregnancy: a retrospective study of prescription patterns and birth outcomes at an antenatal clinic in rural Ghana(2017)

Effects of prenatal antibiotic treatment on early infant health: a retrospective study in a rural health facility in Ghana(2023)

Anxiolytic and Antidepressant Effects of a Leaf Extract of Palisota hirsuta K. Schum. (Commelinaceae) in Mice(2009)

In vivo assessment of the toxic potential of Dissotis rotundifolia whole plant extract in Sprague–Dawley rats(2016)

Toxicological evaluation and protective effect of ethanolic leaf extract of Launaea taraxacifolia on gentamicin induced rat kidney injury(2017)

Toxicity studies on Alchornea cordifolia leaf extract in mince(2009)

Terminalia ivorensis A. Chev. Ethanolic Stem Bark Extract Protects Against Gentamicin-Induced Renal and Hepatic Damage in Rats(2016)

Subacute Oral Toxicity Assessment of Alchornea cordifolia (Schumach and Thonn) Müll Arg (Euphorbiaceae) Extract in Rats(2011)

Effect of Aqueous Extract of Euphorbia hirta on Haematological and Biochemical Parameters of Sprague Dawley Rats(2013)

Toxicological assessment of Parquetina nigrescens extracts in rats(2007)

Polyherbal renal tea extract shows anti-inflammatory and antioxidant effects against gentamicin-induced nephrotoxicity in guinea pigs(2024)

DNA damage protecting activity and antioxidant potential of Launaea taraxacifolia leaves extract(2018)

Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes(2020)

Antiplasmodial and Antipyretic Activity and Safety Evaluation of the Methanolic Leaf Extract of Murraya exotica (L.)(2020)

Pharmacotherapy of infertility in Ghana: Why do infertile patients discontinue their fertility treatment?(2022)

Psychological distress of Ghanaian couples after unsuccessful treatment for infertility(2023)

Pharmacotherapy of infertility in Ghana: retrospective study at the cape coast teaching hospital(2019)

Pharmacotherapy for Infertility in Ghana: A Prospective Study on Prescription Patterns and Treatment Outcomes among Women undergoing Fertility Treatment(2023)

Coping strategies of Ghanaian couples after unsuccessful infertility treatment: An exploratory qualitative study(2025)

Anti-Arthritic Effects of Palisota hirsuta K. Schum. Leaf Extract in Freund’s Adjuvant-Induced Arthritis in Rats(2009)

Irrational use of antibiotics and the risk of diabetes in Ghana(2016)

AQUEOUS LEAF EXTRACT OF CARICA PAPAYA (CARICACEAE) LINN. CAUSES LIVER INJURY AND REDUCED FERTILITY IN RATS(2016)

Anti-Inflammatory and antipyretic effects of an ethanolic extract of Palisota hirsuta K. Schum roots(2008)

Anti-Nociceptive Effects and the Mechanism of Palisota hirsuta K. Schum. Leaf Extract in Murine Models(2009)

Anti-inflammatory and Antipyretic Effects of an Ethanolic Extract of Capparis erythrocarpos Isert Roots(2011)

Anti-inflammatory and antioxidant properties of the root extract of Carissa edulis (forsk.) Vahl (apocynaceae)(2008)

Anti-Nociceptive Effects of an Ethanolic Extract of the Whole Plant of Synedrella nodiflora (L.) Gaertn in Mice: Involvement of Adenosinergic Mechanisms(2008)

Anti-arthritic and antioxidant properties of the ethanolic stem bark extract of Newbouldia laevis (P. Beauv.) Seaman ex Bureau (Bignoniaceae)(2008)

Anxiogenic-like Effects of a Root Extract of Sphenocentrum jollyanum Pierre in Murine Behavioural Models(2009)

Responses of genes involved in cell cycle control to diverse DNA damaging chemicals in human lung adenocarcinoma A549 cells.(2005)

Trichilia monadelpha Bark Extracts Inhibit Carrageenan-Induced Foot-Oedema in the 7-Day Old Chick and the Oedema Associated with Adjuvant-Induced Arthritis in Rats(2011)

In vitro H+/K+-ATPase Inhibition, Antiradical effects of a flavonoid-rich fraction of Dissotis rotundifolia, and In silico PASS Prediction of its isolated compounds(2018)

Antinociceptive Effects of an Ethanolic Extract of Capparis erythrocarpos Isert Roots in the Mice Formalin Test(2009)

Anxiogenic Effects of an Aqueous Crude Extract of Cryptolepis sanguinolenta (Periplocaceae) in Mice(2007)

Antidepressant-Like Effects of an Ethanolic Extract of Sphenocentrum jollyanum Pierre Roots in Mice(2008)

Assessment of an ethanolic seed extract of Picralima nitida ((Stapf) Th. and H. Durand) on reproductive hormones and its safety for use(2015)

Ethanolic stem bark extract of Terminalia ivorensis A. Chev. protects against potassium dichromate–induced nephrotoxicity in rats(2020)

Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage(2020)

Antinociceptive activity of the ethanolic extract of the root bark of Cassia sieberiana (Fam. Caesalpinaceae)(2008)

Pharmacovigilance of herbal medicines in Ghana- Knowledge, perception and practice(2025)

Effects of Tetrapleura Tetraptera (Taub) Fruit Extract On Some Isolated Tissues: Possible Mechanism(S) of Antihypertensive Action(2008)

Alchornea Cordifolia (Euphorbiaceae), the Major Constituent of Antiasthmatic Herbal Formulations in Ghana, Stimulates β- adrenoceptors.(2009)

Characterization and Treatment of Severe Malaria in Hospitalized Children at a Ghanaian District Hospital(2009)

SPATHODEA CAMPANULATA EXTRACT ATTENUATES ACETAMINOPHEN-INDUCED HEPATIC INJURY IN MICE(2013)

Effect of an ethanolic seed extract of Picralima nitida ((Stapf) Th. and H. Durand) on reproductive abilities and developmental indices in rodents(2015)

The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways(2022)

Pharmacological Evaluation Of A Popular Polyherbal Preparation, Femitol, Used For The Management Of Uterine Fibroids(2025)

Multimerization approach to improve a cell surface plectin binding cancer stem cell targeted peptoid drug-lead(2025)

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About This Profile

This profile is generated from publicly available publication metadata and is intended for research discovery purposes. Themes, summaries, and trajectories are inferred computationally and may not capture the full scope of the lecturer's work. For authoritative information, please refer to the official KNUST profile.